2. Signaling Pathways
  3. PROTAC
  4. Ligands for Target Protein for PROTAC

Ligands for Target Protein for PROTAC

Target Protein-binding Moiety

Ligands for Target Protein for PROTAC

Related Products

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The PROTAC molecule consists of a target protein ligand and an E3 ubiquitin ligase ligand, with a linker binds them together. The ligand for target protein will lead to attachment of a PROTAC to the proteins of interest for ubiquitin and subsequent degradation.

Target proteins are usually proteins whose overexpression or accumulation may play important roles in the progress of diseases. Numbers of PROTACs have been developed to degrade kinases (such as MEK, KRAS, CDK and Bcr/Abl), transcription factors (such as p53, STAT, RAR, ER and AR), epigenetic tools (such as HDAC and BET bromodomain) and E3 ligase themselves (such as MDM2).

Ligands for Target Protein for PROTAC Related Products (252):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-170450
    AR ligand-38
    AR ligand-38 is the ligand for androgen receptor, that can be used for synthesis of PROTAC AR Degrader-9 (HY-170448).
    AR ligand-38
  • HY-168287
    HDAC3/8 ligand-1
    HDAC3/8 ligand-1 (compound 40) is a ligand for target protein for PROTAC that can be used in the synthesis of YX968 (HY-164233).
    HDAC3/8 ligand-1
  • HY-162738
    JMV6944 2871774-93-3
    JMV6944 is a PXR agonist. JMV6944 competitively inhibits hPXR ligand-binding domain (LBD) binding to PXR with an IC50 of 680nM. JMV6944 induces CYP3A4 mRNA expression in freshly isolated human primary human hepatocyte cultures. JMV6944 can be used for the synthesis of PROTAC PXR degrader JMV7048 (HY-162704).
    JMV6944
  • HY-159573
    Napabucasin analogue 1133287-34-9
    Thalidomide acid is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). Thalidomide acid can be used in synthesis Napabucasin (HY-13919).
    Napabucasin analogue
  • HY-161709
    FLT3/CDKs ligand-1 2452019-67-7
    FLT3/CDKs ligand-1 (Compound 14) is a ligand for target protein, which promotes the degradation of cyclin-dependent kinase (CDK) and the FMS-like tyrosine kinase 3 (FLT3), inhibits FLT3/CDK related proliferations and survivals of leukemia cells. LT3/CDKs ligand-1 can be used for synthesis of PROTAC FLT3/CDKs degrader-1 (HY-161708).
    FLT3/CDKs ligand-1
  • HY-151475
    GID4 Ligand 1 3031442-96-0
    GID4 Ligand 1 (compound 88) is a cell-permeable and high-selective GID4 binder (IC50=5.4 μM; Kd=5.6 μM), binds to GID4 in cells (EC50=558 nM). GID4 Ligand 1 can be used for the synthesis of PROTACs.
    GID4 Ligand 1
  • HY-168658
    CDK12/13 ligand 2
    CDK12/13 ligand 2 is a potent CDK12 and CDK13 ligand. CDK12/13 ligand 2 can be used to synthesize YJ1206 (HY-168555).
    CDK12/13 ligand 2
  • HY-161452
    SOS1 Ligand intermediate-3
    SOS1 Ligand intermediate-3 (Compound 5) is an SOS1 binder that can be used together with pomalidomide (HY-10984) for the synthesis of SOS1 PROTACs.
    SOS1 Ligand intermediate-3
  • HY-168545
    TTK ligand 3
    TTK ligand 3 (Compound 5) is a ligand of monopolar spindle 1 (Mps1, TTK) that can be used in the synthesis of PROTAC (HY-168543).
    TTK ligand 3
  • HY-168038
    PIN1 ligand-1 3038591-92-0
    PIN1 ligand-1 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). PIN1 ligand-1 can be used for synthesis PROTAC PIN1 degrader-1 (HY-168037).
    PIN1 ligand-1
  • HY-48932
    IRAK4 ligand-12 2573304-97-7
    IRAK4 ligand-12 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). IRAK4 ligand-12 can be used for the synthesis of KTX-951 (HY-148290).
    IRAK4 ligand-12
  • HY-171027
    PTP1B/TC-PTP IN-1 3053414-48-2
    PTP1B/TC-PTP IN-1 is a PTP1B and TC-PTP dual inhibitor. PTP1B/TC-PTP IN-1 can be used as a target protein ligand for the synthesis of DU-14 (PTP1B/TC-PTP PROTAC) (HY-164864).
    PTP1B/TC-PTP IN-1
  • HY-162814
    SMARCA2/4-ligand-3
    SMARCA2/4-ligand-3 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). SMARCA2/4-ligand-3 can be used for synthesis PROTAC SMARCA2/4-degrader-25 (HY-162813).
    SMARCA2/4-ligand-3
  • HY-169158
    Bortezomib analog 1
    Bortezomib analog 1 is an analog of Bortezomib (HY-10227). Bortezomib analog 1 and can be used to synthesize PROTAC 20S proteasome subunit β5 degrader 1 (HY-169134).
    Bortezomib analog 1
  • HY-168319
    PI3Kγ ligand 1 2769753-45-7
    PI3Kγ ligand 1 is a Ligand for Target Protein for PROTAC (HY-137340) .
    PI3Kγ ligand 1
  • HY-159596
    Naphthyridin-Me-dimethoxybenzene-COOH
    Naphthyridin-Me-dimethoxybenzene-COOH is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). Naphthyridin-Me-dimethoxybenzene-COOH can be used in synthesis CW-3308 (HY-159579).
    Naphthyridin-Me-dimethoxybenzene-COOH
  • HY-161973
    Hydroxyl-ML-210
    Hydroxyl-ML-210 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). Hydroxyl-ML-210 can be used for synthesis ZX782 (HY-161972).
    Hydroxyl-ML-210
  • HY-161990
    BCL6 ligand-2
    BCL6 ligand-2 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). BCL6 ligand-2 can be used for synthesis DZ-837 (HY-161989).
    BCL6 ligand-2
  • HY-160151
    TP1L
    TP1L is a selective TC-PTP PROTAC degrader for cancer immunotherapy with a DC50 value of 35.8 nM.
    TP1L
  • HY-125001
    JH-VIII-49 2209084-73-9
    JH-VIII-49 (compound 10) is a potent and selective CDK8 inhibitor (IC50=16 nM) with excellent biological activity. JH-VIII-49 promotes CDK8 inhibition through its steroid backbone design. JH-VIII-49 can be used in the synthesis of PROTAC as a target protein ligand of JH-XI-10-02 (HY-111518).
    JH-VIII-49